Correction: Corrigendum: Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

Review: exercise training reduces HbA1c levels but not body mass in type 2 diabetes mellitus.

Elevated anthranilic acid plasma concentrations in type 1 but not type 2 diabetes mellitus.

Experimental data suggested involvement of tryptophan (Trp) - kynurenine (Kyn) pathway (TKP) in mechanisms of autoimmune, type 1 (T1D), and metabolic, type 2 (T2D), diabetes. However, clinical evaluations of TKP metabolites were limited to T2D. We assessed Trp, Kyn and TKP metabolites: anthranilic (AA), kynurenic (KYNA) and xanthurenic (XA) acids, in plasma samples of fifteen T1D, thirty T2D pa...

Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus.

Oxidative stress decreases the bioavailability of endothelium-derived nitric oxide in diabetic patients. We investigated whether impaired endothelium-dependent vasodilation (EDV) in diabetes can be improved by long-term administration of oral antioxidants. Forty-nine diabetic subjects [26 Type 1 (T1) and 23 Type 2 (T2)] and 45 matched healthy control subjects were randomized to receive oral vit...

Insulin Degludec improves Blood Glucose but Does Not Alter Arterial Stiffness in Type 1 Diabetes Patients

Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency.Insulin degludec is newly developed ultra-long-acting insulin analog. However, the effect of insulin degludec on the artery is unclear. Aim:To study the efficacy of insulin degludec on artery. Methods: 28T1DM patients already onbasalbolus insulin therapy were enrolled.Patients were divided into a group that switc...

Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse.

The development of type 1 diabetes (T1D) has been linked to environmental factors and dietary components. Increasing evidence indicates that the integrity of the gut mucosa plays a role in the development of autoimmune diseases, and evidence from both preclinical and clinical studies demonstrates that increased leakiness of the intestinal epithelium precedes the development of type 1 diabetes. ...